You should not do anything unless you (a)are having performance problemsAND (b) you know with absolute certainty that the performance problems can be fixed by making manual changes to the statistics or the statistics-gathering process.
Otherwise... do not touch anything. If you have changed something (an option setting, for example) change it back.
If you are not having performance problems, do not go looking for trouble. SQL Anywhere's behavior and initial option settings have been carefully designed to work well without manual changes. SQL Anywhere is not the same as ASE, or SQL Server, or Oracle, or MySQL, or DB2.
If you are having performance problems, post those questions here!